Publikationen des TR 22 im Jahr 2006

Beisswenger, C., K. Kandler, C. Hess, H. Garn, K. Felgentreff, M. Wegmann, H. Renz, C. Vogelmeier, and R. Bals.
Allergic airway inflammation inhibits pulmonary antibacterial host defense.
J Immunol 2006;177:1833-1837

Felgentreff, K., C. Beisswenger, M. Griese, T. Gulder, G. Bringmann, and R. Bals.
The antimicrobial peptide cathelicidin interacts with airway mucus.
Peptides 2006;27:3100-3106

Kandler, K., R. Shaykhiev, P. Kleemann, F. Klescz, M. Lohoff, C. Vogelmeier, and R. Bals.
The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands.
Int. Immunol. 2006;18:1729-36

Liu, P. T., S. Stenger, H. Li, L. Wenzel, B. H. Tan, S. R. Krutzik, M. T. Ochoa, J. Schauber, K. Wu, C. Meinken, D. L. Kamen, M. Wagner, R. Bals, A. Steinmeyer, U. Zugel, R. L. Gallo, D. Eisenberg, M. Hewison, B. W. Hollis, J. S. Adams, B. R. Bloom, and R. L. Modlin.
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science 2006;311:1770-1773

Schiemann F, Grimm TA, Hoch J, Gross R, Petersen F, Lindner B, Bulfone-Paus S, Brandt E.
Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counter-regulation by PF-4 through inhibition of chymase and cathepsin G.
Blood 2006; 107:2234-2242

Petersen A, Suck R, Lindner B, Georgieva D, Ernst M, Notbohm H, Wicklein D, Cromwell O, Becker WM.
Phl p 3: structural and immunological characterization of a major allergen of timothy grass pollen.
Clin Exp Allergy. 2006 Jun;36:840-9.

Maheshwari A, Zemlin M.
Ontogeny of the Intestinal Immune System.
Haematologica Reports 2006;10:18-26

Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin, Gartland GL, Nitschke L, Pelkonen J,Fujihashi K, Rajewsky K, Schroeder HW Jr.
Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production.
J Exp Med. 2006;203:1567-78

Gibbs BF, Rathling A, Zillikens D, Huber M, Haas H.
Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophile signaling and deactivation.
J.Allergy Clin.Immunol. 2006;118:1060-7.

Hahn C, Pirayesh I, Renz H, Nockher WA.
Airway epithelial cells produce neurotrophins and promote the survival of eosinophils during allergic airway inflammation.
J Allergy Clin Imun, April;2006: 787-794

Publikationen 2007

Zemlin M, Hoersch G, Zemlin C, Pohl-Schickinger A, Hummel M, Berek C, Maier RF, Bauer K.
The postnatal maturation of the Immunoglobulin heavy chain IgG Repertoire in human preterm neonates is slower than in term neonates.
The Journal of Immunology. 2007; 178: 1180 – 1188

Hamm S, Heit A, Koffler M, Huster K.M., Akira S, Busch D.H., Wagner H, Bauer S.
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.
Int. Immunol.2007;19:297-304.

Blumer N, Sel S, Virna S, Patrascan CC, Zimmermann S, Herz U, Renz H, Garn H.
Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring.
Clin Exp Allergy. 2007;37:348-57.

Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J, Sparwasser T.
Related Articles, Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007;204: 57-63.

Publikationen 2008

Huber M, Brüstle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Löw E, Lohoff M.
IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20846-51.

Zemlin M, Schelonka RL, Ippolito GC, Zemlin C, Zhuang Y, Gartland GL, Nitschke L, Pelkonen J, Rajewsky K, Schroeder HW Jr.
Regulation of repertoire development through genetic control of DH reading frame preference.
J Immunol. 2008 Dec 15;181(12):8416-24.

Schelonka RL, Zemlin M, Kobayashi R, Ippolito GC, Zhuang Y, Gartland GL, Szalai A, Fujihashi K, Rajewsky K, Schroeder HW Jr.
Preferential use of DH reading frame 2 alters B cell development and antigen-specific antibody production.
J Immunol. 2008 Dec 15;181(12):8409-15.

Hanuszkiewicz A, Hübner G, Vinogradov E, Lindner B, Brade L, Brade H, Debarry J, Heine H, Holst O.
Structural and immunochemical analysis of the lipopolysaccharide from Acinetobacter lwoffii F78 located outside Chlamydiaceae with a Chlamydia-specific lipopolysaccharide epitope.
Chemistry. 2008;14(33):10251-8.

Schaub B, Liu J, Schleich I, Höppler S, Sattler C, von Mutius E.
Impairment of T helper and T regulatory cell responses at birth.
Allergy. 2008 Nov;63(11):1438-47.

Publikationen 2009

Stelekati E, Bahri R, D'Orlando O, Orinska Z, Mittrücker HW, Langenhaun R, Glatzel M, Bollinger A, Paus R, Bulfone-Paus S.
Mast cell-mediated antigen presentation regulates CD8+ T cell effector functions.
Immunity. 2009 Oct 16;31(4):665-76.

Pinto L, Depner M, Steudemann L, Klopp N, Illig T, von Mutius E., Kabesch M.
IL15 gene variants are not associated with asthma and atopy.
Allergy. 2009 Apr;64(4):643-6.

Suttner K, Ruoss I, Rosenstiel P, Depner M, Pinto LA, Schedel M, Adamski J, Illig T, Schreiber S, von Mutius E, Kabesch M.
HLX1 gene variants influence the development of childhood asthma.
J Allergy Clin Immunol. 2009 Jan;123(1):82-88.e6.

Kormann MS, Ferstl R, Depner M, Klopp N, Spiller S, Illig T, Vogelberg C, von Mutius E, Kirschning CJ, Kabesch M.
Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk.
Allergy. 2009 Apr;64(4):636-42.

Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto LA, Ruether A, Adamski J, Klopp N, Illig T, Vogelberg C, Schreiber S, von Mutius E, Kabesch M.
TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.
J Allergy Clin Immunol. 2009 May;123(5):1062-8, 1068.e1-8.

Herr C, Beisswenger C, Hess C, Kandler K, Suttorp N, Welte T, Schroeder JM, Vogelmeier C, R Bals.
Suppression of pulmonary innate host defence in smokers.
Thorax. 2009 Feb;64(2):144-9.

Abram M, Wegmann M, Fokuhl V, Sonar S, Luger EO, Kerzel S, Radbruch A, Renz H, Zemlin M.
Nerve growth factor and neurotrophin-3 mediate survival of pulmonary plasma cells during the allergic airway inflammation.
J Immunol. 2009 Apr 15;182(8):4705-12.

Kerzel S, Wagner J, Rogosch T, Yildirim AO, Sikula L, Fehrenbach H, Garn H, Maier RF, Schroeder HW Jr, Zemlin M.
Composition of the immunoglobulin classic antigen-binding site regulates allergic airway inflammation in a murine model of experimental asthma.
Clin Exp Allergy. 2009 Apr;39(4):591-601.

Blume C, Foerster S, Gilles S, Becker WM, Ring J, Behrendt H, Petersen A, Traidl-Hoffmann C.
Human epithelial cells of the respiratory tract and the skin differentially internalize grass pollen allergens.
J Invest Dermatol. 2009 Aug;129(8):1935-44.

Wagner C, Isermann K, Roeder T.
Infection induces a survival program and local remodeling in the airway epithelium of the fly.
FASEB J. 2009 Jul;23(7):2045-54.

Roeder T, Isermann K, Kabesch M.
Drosophila in asthma research.
Am J Respir Crit Care Med. 2009 Jun 1;179(11):979-83.

Carlens J, Wahl B, Ballmaier M, Bulfone-Paus S, Förster R, Pabst O.
Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine.
J Immunol. 2009 Nov 1;183(9):5600-7.Click here to read

Schaub B, Liu J, Höppler S, Schleich I, Huehn J, Olek S, Wieczorek G, Illi S, von Mutius E.
Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells.
J Allergy Clin Immunol. 2009 Apr;123(4):774-82.e5.

Klein MK, Haberberger RV, Hartmann P, Faulhammer P, Lips KS, Krain B, Wess J, Kummer W, König P.
Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.
Eur Respir J. 2009 May;33(5):1113-21.

König P, Krain B, Krasteva G, Kummer W.
Serotonin increases cilia-driven particle transport via an acetylcholine-independent pathway in the mouse trachea.
PLoS One. 2009;4(3):e4938.

Schramm G, Hamilton JV, Balog CI, Wuhrer M, Gronow A, Beckmann S, Wippersteg V, Grevelding CG, Goldmann T, Weber E, Brattig NW, Deelder AM, Dunne DW, Hokke CH, Haas H, Doenhoff MJ.
Molecular characterisation of kappa-5, a major antigenic glycoprotein from Schistosoma mansoni eggs.
Mol Biochem Parasitol. 2009 Jul;166(1):4-14.

Conrad ML, Yildirim AO, Sonar SS, Kiliç A, Sudowe S, Lunow M, Teich R, Renz H, Garn H.
Comparison of adjuvant and adjuvant-free murine experimental asthma models.
Clin Exp Allergy. 2009 Aug;39(8):1246-54.

Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Köhl J, Finkelman FD.
Peanuts can contribute to anaphylactic shock by activating complement.
J Allergy Clin Immunol. 2009 Feb;123(2):342-51.

Zhang X, Lewkowich IP, Köhl G, Clark JR, Wills-Karp M, Köhl J.
A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells.
J Immunol. 2009 Apr 15;182(8):5123-30.

Suttner K, Depner M, Klopp N, Illig T, Vogelberg C, Adamski J, von Mutius E, Kabesch M.
Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children.
J Allergy Clin Immunol. 2009 May;123(5):1179-81.

Luger EO, Fokuhl V, Wegmann M, Abram M, Tillack K, Achatz G, Manz RA, Worm M, Radbruch A, Renz H.
Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge.
J Allergy Clin Immunol. 2009 Oct;124(4):819-26.e4.

Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T.
Nonfunctional regulatory T cells and defective control of th2 cytokine production in natural scurfy mutant mice.
J Immunol. 2009 Nov 1;183(9):5

Wagner C, Isermann K, Roeder T.
Infection induces a survival program and local remodeling in the airway epithelium of the fly.
FASEB J. 2009 Jul;23(7):2045-54.

Röschmann K, Farhat K, König P, Suck R, Ulmer AJ, Petersen A.
Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non-protease mechanism.
Clin Exp Allergy. 2009 Sep;39(9):1358-69.

Schiemann F, Brandt E, Gross R, Lindner B, Mittelstädt J, Sommerhoff CP, Schulmistrat J, Petersen F.
The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4.
J Immunol. 2009 Aug 15;183(4):2223-31.

Suttner K, Rosenstiel P, Depner M, Schedel M, Pinto LA, Ruether A, Adamski J, Klopp N, Illig T, Vogelberg C, Schreiber S, von Mutius E, Kabesch M.
TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.
J Allergy Clin Immunol. 2009 May;123(5):1062-8, 1068.e1-8.

Roeder T, Isermann K, Kabesch M.
Drosophila in asthma research.
Am J Respir Crit Care Med. 2009 Jun 1;179(11):979-83.

Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker H-W, Brüstle A, Kamradt T, Lohoff M.
Reciprocal relation between cytotoxic and type 17 CD8+ developmental programs. 2009.
Eur. J. Immunol. 39:1716-1725.

Publikationen 2010

Möbs C, Slotosch C, Löffler H, Jakob T, Hertl M, Pfützner W.
Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation.
J Immunol. 2010 Feb 15;184(4):2194-203.

Zhang X, Köhl J.
A complex role for complement in allergic asthma.
Expert Rev Clin Immunol. 2010 Mar;6(2):269-77. Review.

VIsekruna A, Huber M, Hellhund A, Bothur E, Reinard K, Bollig N, Schmidt N, Joeris T, Lohoff M, Steinhoff U.
c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17.
Eur J Immunol. 2010 Mar; 40(3):671-6.

Alalwani SM, Sierigk J, Herr C, Pinkenburg O, Gallo R, Vogelmeier C, Bals R.
The antimicrobial peptide LL-37 modulates the inflammatory and host defense resonse of human neutrophils.
Eur J Immunol. 2010 Apr;40(4):1118-26.

Abdelsadik A, Roeder T.
Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes.
BMC Genomics. 2010 Apr 26;11:265.

Rogosch T, Kerzel S, Sikula L, Gentil K, Liebetruth M, Schlingmann KP, Maier RF, Zemlin M.
Plasma cells and nonplasma B cells express differing IgE repertoires in allergic sensitization.
J Immunol. 2010 May 1;184(9):4947-54.

Debarry J, Hanuszkiewichz A, Stein K, Holst O, Heine H.
The allergy-protective properties of Acinetobacter lwoffii F78 are imparted by its lipopolysaccharide.
Allergy. 2010 Jun 1;65(6):690-7.

Suttner K, Depner M, Wetzke M, Klopp N, von Mutius E, Illig T, Sparwasser T, Kabesch M.
Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk.
J Allergy Clin Immunol. 2010 Jun;125(6):1395-9.

Sonar SS, Schwinge D, Kilic A, Yildirim AO, Conrad ML, Seidler K, Müller B, Renz H, Nockher WA.
Nerve growth factor enhances Clara cell proliferation after lung injury.
Eur Respir J. 2010 Jul;36(1):105-15.

Kerzel S, Rogosch T, Struecker B, Maier RF, Zemlin M.
IgE transcripts in the circulation of allergic children reflect a classical antigen-driven B cell response and not a superantigen-like activation.
J Immunol. 2010 Aug 15;185(4):2253-60.

Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E, Bopp T.
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Immunity. 2010 Aug 27;33(2):192-202.

Baru AM, Hartl A, Lahl K, Krishnaswamy JK, Fehrenbach H, Yildirim AO, Garn H, Renz H, Behrens GM, Sparwasser T.
Selective depletion of Foxp3(+) Treg during sensitization phase aggravates experimental allergic airway inflammation.
Eur J Immunol. 2010 Aug;40(8):2259-66.

Orinska Z, Föger N, Huber M, Marschall J, Mirghomizadeh F, Du X, Scheller M, Rosenstiel P, Goldmann T, Bollinger A, Beutler BA, Bulfone-Paus S.
1787 provides signals for c-Kit  receptor internalization and functionality that control mast cell survival and development.
Blood. 2010 Oct14;116(15):2665-75.

Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S, Tschopp J, Layland LE, Prazeres da Costa C.
Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.
Proc Natl Acad Sci USA. 2010 Nov 23;107(47):20459-64.

Pfefferle PI, Pinikenburg O, Renz H.
Fetal epigenetic mechanisms and innate immunity in asthma.
Curr Allergy Rep. 2010 Nov;10(6):434-43.

Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, König P, Gerard NP, Gerard C, Wills-Karp M, Köhl J.
A critical role for C5L2 in the pathogenesis of experimental allergic asthma.
J Immunol. 2010 Dec 1;185(11):6741-52.

Shaykhiev R, Sierigk J, Herr C, Krasteva G, Kummer W, Bals R.
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS.
FASEB J. 2010 Dec;24(12):4756-66.

Publikationen 2011

Marsh LM, Pfefferle PI, Pinkenburg O, Renz H.
Maternal Signals for progeny prevention against allergy and asthma. 
Cell Mol Life Sci. 2011. (Epub ahead of print) Review.

Ege MJ,  Mayer M, Normand AC, Genuneit J, Cookson WO, Braun-Fahrländer C, Heederik D, Piarroux R, von Mutius E; GABRIELA Transregio22 Study Group.
Exposure to environmental microorganisms and childhood asthma.
N Engl J Med. 2011 Feb 24; 364(8):701-9.

Liu J, Rädler D, Illi S, Klucker E, Turan E, von Mutius E, Kabesch M, SChaub B.
TLR2 polymorphisms influence neonatal regulatory T cells depending on maternal atopy.
Allergy. 2011 Mar4. doi:10.1111/j.1398-9995.2011.02573.x. (Epub ahead of print).